A federal appeals court has upheld the life sentence of a man in a case hailed as the nation’s largest seizure of an operable LSD lab.

The 10th U.S. Circuit Court of Appeals in Denver on Tuesday rejected the appeals by William Leonard Pickard of Mill Valley, Calif., and co-defendant Clyde Apperson of Sunnyvale, Calif.

The two were arrested near a former missile silo near Wamego, Kan., where Drug Enforcement Administration agents said the LSD lab had been hidden.